How important is a direct train to work in everyday life?

Hi everyone!
I’m moving to Tokyo soon and am looking for places to live. I’ve heard that most people will pick accomodation that allows them to have a direct train to work.
The areas I want to live in don’t have direct trains to my office (Im wanting to live around Nakameguro, Sangenjaya area and will be working in Otemachi).
I would rather change trains than compromise on where I’m living but I’m not sure if I’ll regret this.
How inconvenient will this really be, enough that I could regret my choice of suburb?
Thank you!
Edit: fixed my incorrect spelling of Otemachi

by Hour_Budget3290

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